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On the other hand, the same concentration of Earn although not other CB1R agonists, improves intracellular Ca2+ concentration through Gq/eleven protein in transfected HEK-293 cells and cultured hippocampal neurons with endogenous receptor expression [93]. What's more, in mice hippocampal slices, CB1R expressed in astrocytes is coupled to Gq/eleven,
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